Teva closes agreement to develop  fremanezumab in Japan

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Tevas investigational drug candidate fremanezumab (TEV-48125), an anti-calcitonin gene-related peptide (CGRP) monoclonal antibody for the prevention of migraine, is administered monthly as a subcutaneous injection. The company has signed an agreement with Otsuka Pharmaceutical to develop and commercialize the product in Japan. Otsuka will pay Teva a lump-sum payment of $50 million. Milestone payments will be made upon filing and regulatory approval in Japan and then upon achievement of specified revenue targets. Future clinical trials in Japan will be carried out and funded by Otsuka.

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